“light” versus “classic” laser treatment for clinically significant diabetic macular oedema - green laser distance measurer

Alimactaim: compare the effectiveness of "light" and "classic" laser coagulation in diabetic patients with clinically significant edema (CSMO).
Methods: A prospective randomized pilot clinical trial in which 29 eyes of 24 patients with mild to moderate non-diabetes
Diabetic kidney disease with proliferation (NPDR)
CSMO is randomly divided into "classic" or "light" Nd: YAG 532 nm (
Double frequency)green laser.
The laser treatment of "light" is different from the traditional one (“classic”)
Light coagulation, because the energy used is the lowest energy to produce almost invisible burns at the level of the retinal pigment epithelial.
The main result measurement is a change in the thickness of the central concave retina measured by optical coherent tomography (OCT);
Secondary results were reduction/elimination of edema in contact lenses biomicroscopy and fluorescence angiography, changes in vision, contrast sensitivity, and mean deviation of the Central 10 ° field of vision.
The inspectors covered the patient's treatment.
Results: 14 Eyes were assigned to "classic" and 15 to "light" laser therapy.
12 months, 7 months50%)
Of 14 eyes treated with "classics" and six (43%)
On October, the central concave retinal thickness of 14 eyes treated with "light" laser decreased (
When the hypothesis of the X2 test is not verified, Fisher's exact test is used.
Shapiro-tests the normality of the distribution of continuous variablesWilk test.
Inter-group comparison of continuous variables with t-test or Mann-test
According to Shapiro's test
Wilk test results
Comparison of continuous variables in the group with baseline differences using a paired t-test or Wilcoxon test also depends on Shapiro-
Wilk test results
All analyses were performed using SPSS 11, a statistical software. 1.
Results a total of 29 eyes of 24 patients were randomly divided into "classic" or "light" laser coagulation;
14 Eyes received "classic" laser treatment and 15 Eyes received "light" laser treatment.
Five patients received bilateral treatment and 19 patients received unilateral treatment.
On October, one eye in the "light" group had no data;
Therefore, it was excluded from the data analysis in October.
Table 1 gives the baseline variables for each group.
The system, function and morphological features of the two groups were similar, with no statistical difference.
Table 2 summarizes the results of 12 months in a single patient.
Table 3 compares the results measurements of the two study groups for 3, 6 and 12 months.
For any outcome measurement, no statistically significant differences were found, except for the eye ratio that experienced five or more letter visual gain at 6 months, larger in the "light" group.
In any subsequent visits, the mean FTH of the two groups did not change significantly compared to baseline.
The initial median vision remained unchanged at 12 months in both groups, all at 20/32.
At 3, 6 and 12 months of follow-up, 5 (36%), seven (50%), and seven (50%)
With "classic" and four (29%), six (43%), and six (43%)
In October, the FTH of 14 eyes treated with "light" laser decreased (121:1303–10.
Research Group on early treatment of diabetic kidney disease.
Light coagulation treatment of diabetic retinal edema
Report on early treatment of diabetic kidney disease 1.
1985 out of the eye; 103:1796–806.
CM, RJ of OpenUrlCrossRefPubMedWeb Science solar Lee is OK.
Treatment of diffuse diabetic retinal edema with modified grid-like laser coagulationLong-
Visual results.
Ophthalmology 199198:1594–602.
L of OpenUrlPubMedWeb Science alimakduman, RJ is OK. Diode laser (810 nm)
Green to argon (514 nm)
Treatment of diffuse diabetic retinal edema with modified grid-like light coagulation
Ophthalmology 1997104:1433–41.
GG, WM Hart Jr, RJ of OpenUrlPubMedWeb Science Limited Striph is OK.
Treatment of diabetic retinal edema with modified grid-like laser coagulation
The impact on the central vision.
Ophthalmology 198895:1673–9.
Scientific OpenUrlPubMedWeb sinclair SH, Alaniz R, Presti P.
Laser treatment of diabetic edema: Comparison of ETDRS-
Threshold level processing-
Through the use of high-level treatment
Contrast the visual field test of the discrimination center.
Ophthalmology department of scanning electron microscope 1999; 4:214–22.
OpenUrl Hudson C, that JG, Turner GS, etc.
Effect of laser coagulation on diabetic edema with significant clinical significance (DMO)on short-
Automatic field of view measurement of wavelength and tradition.
Diabetes 1998; 41:1283–92.
The high of OpenUrlCrossRefPubMedWeb Science GmbH Schatz, Madeira, McDonald's hours, etc.
The gradual expansion of laser scar after grating laser coagulation treatment of diffuse diabetes edema.
1991 out of the eye; 109:1549–51.
The height of OpenUrlCrossRefPubMedWeb Science GmbH Lewis, Schachat AP, Haimann MH, etc.
New blood vessels of retina after laser coagulation of diabetic retinal edema.
Ophthalmology 199097:503–10.
Dr. OpenUrlPubMedWeb guguyer of science, DJ d Amico, Smith CW.
Diabetic edema subretinal hyperplasia after laser coagulation.
J Ophthalmol 1992 in the morning; 113:652–6.
DP, Mieler WF, Burton TC of OpenUrlPubMedWeb Science hophan.
Subretinal fiber hyperplasia after diabetic retinal edema and light coagulation.
J Ophthalmol 1992 in the morning; 113:513–21.
OpenUrlPubMedWeb for Masters of Science, white TJ, Tips analytics and others. Retinal-
Temperature rise generated by strong light sources.
J. Opt Soc Am 1970; 60:264–70.
TR, Karatza EC, OpenUrlCrossRefPubMedWeb Science limfriberg.
Treatment of retinal diseases using MicroPulse and continuous wave 810-nm diode laser.
Ophthalmology 1997104:20–308.
Openurlroder J, Brinkmann R, Wirbelauer C, etc. Subthreshold (
Retina pigment epithelial)
Light coagulation therapy for retinal diseases: a preliminary study.
Br J Ophthalmol 2000; 84:40–7.
OpenUrlAbstract/free full text in Hamilton AM
Clinical application of micro-pulse diode laser. Eye 1999; 13:145–150. ↵Bresnick GH.
Diabetic papules
Highlight important reviews of diffuse edema.
Ophthalmology 198390:1301–17.
Science of OpenUrlPubMedWeb, Bindley CD.
Light coagulation treatment of diabetic retinal edema
Case report of clinical pathology. Retina 1988; 8:261–9.
OpenUrlPubMedWeb of Science magazine Priore LV, Glaser BM, Quigley HA, etc.
Response of retinal pigment epithelial to laser coagulation in organ culture.
1989 out of the eye; 107:119–22.
J, clover, Rothtery S of OpenUrlCrossRefPubMedWeb ScienceMarshall.
Some new findings from Krypton and ar laser retina irradiation.
In: Birngruber R, Gabel V-P, eds.
Laser treatment and light coagulation of eyes.
Eye doctor handling Series 36.
The Hague: Garbage, 1984: 21-37
Micharoder J, Michaud N, Flotte T, etc.
Response of repeated short laser pulses to selective light coagulation of retinal pigment epithelial cells.
1992 out of the eye; 110:1786–92.
Data warehouse of OpenUrlCrossRefPubMedWeb Science archidowson, Volpert OV, Gillis, etc.
Pigment Epithelial-
Derived factor: An Effective Vascular inhibitor. Science 1999; 285:245–8.
OpenUrlAbstract/free full Text hangogata N, Tombran-
Tink J, Jo N, et al.
Up-regulation of pigment epithelial
Derivative factors after laser coagulation.
Mr. Pulhee, Mr. Puliafito C, Duker JS, et al.
Topographic Study of diabetic edema by optical coherent tomography.
Ophthalmology 1998105:360–70.
P, Erginay A, Haouchine B, etc. of openurlcrossrefpmedweb Science solar Massin.
The retinal thickness of healthy and diabetic subjects was measured using optical coherent tomography mapping software.
Ophthalmol Eur J 2002; 12:102–8.
Scientific OpenUrlPubMedWeb ferris FL 3rd, Kassoff A, Bresnick GH, etc.
New vision chart for clinical research.
J Ophthalmol 1982 in the morning; 94:91–6.
P, Vicaut E, Haouchine B, etc. of OpenUrlPubMedWeb Science GmbH Massin.
Repeatability of Retina mapping using optical coherent tomography.
2001 out of the eye; 119:1135–42.
Marshall J. Science's openurlcrosspubmedweb
Interpretation of retinal optical coherent tomography images.
Invest in Ophthalmol Vis Sci 1999; 40:2332–42.
OpenUrlAbstract/free full TextPolito A, Shah SM, hallja, etc.
Comparison of retina thickness analyzer and optical coherence tomography in evaluating the central concave thickness of the eye for retinal disease.
J Ophthalmol 2002 in the morning; 134:240–51.
DJ, McOwen MD, burnr, and so on at openurlcrossrefpmedweb Science Daily Browning.
Comparison of clinical diagnosis of diabetic edema with optical coherence tomography.
Ophthalmology 2004111:712–15.